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江苏科技信息 ›› 2015, Vol. 32 ›› Issue (34): 63-65,68.doi: 10.3969/j.issn.1004-7530.2015.34.029

• 论文 • 上一篇    下一篇

金属氧化物催化对氟苯乙酮合成研究

王乾, 杨怡   

  1. 常州工程职业技术学院,江苏常州,213164
  • 出版日期:2015-12-05 发布日期:2015-12-05
  • 基金资助:
    江苏省高等学校大学生创新创业训练计划项目%项目名称:药物中间体对氟苯乙酮合成研究%项目(201313102008Y)

Research on the Synthesizing of 1-(4-Fluorophenyl) Ethanone Catalyzed by Metal Oxide Catalyst

Wang Qian, Yang Yi   

  • Online:2015-12-05 Published:2015-12-05

摘要： 对氟苯乙酮是一种重要的化工、医药工业中间体.文章研究了氟苯在金属氧化物催化下,滴加乙酸酐发生Friedel-Crafts酰基化反应,生成对氟苯乙酮.适宜的反应条件为氟苯与催化剂三氧化二铁的摩尔比为1:0.1、氟苯与乙酸酐的摩尔比为2:1,反应温度为80℃下反应6h,对氟苯乙酮的收率达60.8%.

关键词: 三氧化二铁, 酰化反应, 对氟苯乙酮

Abstract: 1-(4-Fluorophenyl) ethanone is an important intermediate of chemical and medical industry. In this article, 1-(4-Fluorophenyl) ethanone was synthesized by using Fluorobenzene and Acetic anhydride as the reactants ,Fe2O3 as the catalyst. The optical conditions were as follows:n(Fluorobenzene):n(Fe2O3 )=1:0.1,n(Fluorobenzene):n(Acetic anhydride)=2:1,the reaction temperature was 80℃ and the reaction time was 4h. The yield of 1-(4-Fluorophenyl) ethanone was 60.8%.